Introduction: Community pharmacies have been recognized globally as playing a crucial role in providing primary and reproductive healthcare services as they are well-positioned to provide adolescents with various reproductive health services. Despite the potential for community pharmacists to provide valuable services that promote adolescent-friendly sexual and reproductive health services (AFSRHS) within the community, limited studies have been conducted in these regions to assess the knowledge levels of community pharmacists regarding AFSRHS or explore their attitudes and practices towards AFSRHS, and how community pharmacies are equipped to provide AFSRHS. Methodology: A quantitative cross-sectional study was conducted using a self-administered electronic questionnaire to collect information on the Knowledge, Attitude and Practices on adolescent friendly sexual and reproductive health services among 192 community pharmacists across four regions. The data was analysed using Stata version 16. Logistic regression was performed to determine factors associated with community pharmacists’ practices towards adolescent friendly sexual and reproductive health services. Results: Majority 138 (71.9%) of pharmacists in community practice had overall inadequate knowledge on Adolescent Friendly Sexual Reproductory Health Services (AFRHS), more than half had overall poor attitudes 102 (53.1%) towards AFRSHS and similarly, more than half 105 (54.7%) had poor practices towards the provision of AFSRHS.  The results show that attitude was significantly associated with practices of community pharmacists towards AFSRHS. Conclusion: The findings of the study suggest significant gaps in knowledge levels, attitudes, and practices of community pharmacists within these regions towards adolescent friendly sexual and reproductive services. The findings also suggest gaps around how community pharmacies conform to the WHO Global Standards for Quality Health-Care Services for Adolescents. Interventions such as training and education is key to enhance the technical competence of community pharmacists. Further studies are needed to elicit more information on other areas of improvement to enable community pharmacies conform to the WHO Global Standards for Quality Health-Care Services for Adolescents.